Equipment

Morphological Phenotyping

  • OCT: Bioptigen Envisu SD-OCT equipment for anterior and posterior segment imaging in zebrafish, mouse, rat, rabbit and large animals.
  • cSLO and FA: Heidelberg Spectralis FA-HRA system, including fluorescein angiography and indocyanine green angiography modules, for imaging from mouse till men.
  • TEFI (Topical Endoscopic Fundus Imaging): high resolution in vivo color photograph of the rodent retina, including peripheral retina and ciliary body

 

HRA OCT

TEFI

Functional and Behavioural Phenotyping

  • Electrophysiology: LKC BigShot set-up dedicated to mice, equipped for recording of flash and pattern ERG, scotopic threshold response (STR) and photopic negative response (PhNR), as well as visual evoked potentials.
  • Extensive software packages and hardware set-ups to assess multiple visual thresholds behaviourally, including visual acuity and contrast sensitivity (Optomotor virtual reality set-up), color, spatial and temporal frequency, orientation, contrast, motion and shape discrimination (dry Y-maze; under development), circadian rhythm and visual cliff test.

Other services

  • IOP measurement to test the effect of IOP-lowering drugs
  • Histological assessment, biochemical characterisation (e.g. ELISA, qPCR, etc.)