In vitro models

We have acces to a whole range of relevant cell types of different origin. We have both mono-culture and co-culture experience. This will allow screening of the compounds of your interest in the different disease processes or determination and/or confirmation of the mechanism of action of your compound.

Angiogenesis

Proliferation, migration, survival and interaction assays

  • Endothelial cells: HUVEC (human umbilical vein EC), HBMEC (human brain microvascular EC)
  • Pericytes

Migration assay

Inflammation

Proliferation, activation and interaction assays

  • Primary monocytes
  • Primary lymphocytes 

Fibrosis

Proliferation, survival, migration and differentiation into myofibroblasts

  • Primary corneal fibroblasts
  • Primary Tenon fibroblasts

HTF

Neurodegeneration

Proliferation, survival and migration assays 

  • Müller cells
  • Microglia
  • Mixed primary retinal cell cultures

All assays can be performed with murine or porcine cells.

Ex vivo assays

Neuronal survival, neurite outgrowth and neuron-glia interactions

  • Retinal explants (mouse, pig)

retinal explant