In vivo models

VCL offers a wide variety of animal models for different ocular pathologies:

  • Age related Macular Degeneration
  • Uveitis
  • Glaucoma
  • Diabetic retinopathy

VCL uses the eye as a model system to obtain insights into mechanisms and processes underlying many human diseases, i.e. pathological angiogenesis, fibrosis, inflammation and neurodegeneration.The models are listed below according to the different pathological processes that are involved.

VCL can help you in selecting the right models for testing of your compounds.

Angiogenesis and Vessel Leakage

  • Laser-induced choroidal neovascularization (AMD)
  • Streptozotocin-induced diabetic retinopathy

Vessel leakage

Inflammation

  • Experimental autoimmune uveitis mouse model (EAU)
  • Endotoxin-induced uveitis mouse model (EIU)
  • Laser-induced choroidal neovascularization (AMD)
  • Streptozotocin-induced diabetic retinopathy

Leukocyte adhesion

 

Fibrosis

  • Glaucoma filtration surgery
  • Laser-induced choroidal neovascularization (AMD)

Fibrosis

Neurodegeneration

  • Laser-induced ocular hypertension (glaucoma)
  • Optic Nerve Crush (glaucoma)
  • NMDA-induced excitotoxicity (glaucoma)
  • Streptozotocin-induced diabetic retinopathy

RGC density

Next to these up-and-running models, VCL is implementing and validating several other models and read-outs for different ocular diseases and disease processes.

Please do not hesitate to contact us to get more information on these models under development.